Welcome to the Laboratory of  Professor Carla  Mattos

Center for Structural Biochemistry at Northeastern University

Our Mission

Understanding structural and functional relationships amongst signaling proteins

Lab News

PhD 17: Dr. Michael Schwabe

Woohoo! Congratulations to Dr. Michael Schwabe for successfully defending his thesis! Thank you for your inquisitive insights and helpful advice! We are excited to see your next step as a PhD scientist!

PhD 16: Dr. Monica Ojeda

Congratulations to Dr. Monica Ojeda! We are so proud of your research achievements in the Mattos lab! We will miss your vibrant energy and wish you all the best in your future scientific endeavors!


Our group had a great time at the Protein Society 36th Annual Symposium in San Francisco. Carla enjoyed connecting with friends Brian Matthews (left) and John Kuriyan (right). Monica, Michael, and Kasun received travel awards to present their posters.

PhD 15: Dr. Morgan Ploch

She did it! We are so excited to congratulate Dr. Morgan Ploch on the successful defense of her thesis. Thanks for your hard work, mentorship, and delicious food over the years!

Welcome to the Lab: Marcela!

We are so excited to welcome Marcela de Barros as the newest member of our lab! Marcela comes to us from Brazil and has extensive experience studying the tyrosinase enzyme. Bem-vinda Marcela!

“This Mysterious On-Off Switch Holds Clues to New Cancer Treatments”

Extra, extra, read all about it: News@Northeastern recently published an article about our work and the grant we recently received from the National Science Foundation.

Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation

Crystalizing the CRD: Nice job Trinity! Our paper published in Biomolecules showcases the first high-resolution structure of the Raf Kinase cystein-rich domain (CRD) bound to Ras providing insight into the role of this domain.Abstract Ras and Raf-kinase interact...

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Digging into Dimerization: Way to go Morgan, Jillian, and the team! Our paper published in PNAS demonstrates robust dimerization of Ras induced by the Ras-binding domain (RBD) of Raf Kinase.Significance Ras GTPases, KRas, HRas, and NRas control cell proliferation via...