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Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation

Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation

by Michael | Sep 2, 2021 | New Publication

Crystalizing the CRD: Nice job Trinity! Our paper published in Biomolecules showcases the first high-resolution structure of the Raf Kinase cystein-rich domain (CRD) bound to Ras providing insight into the role of this domain. Click here to download the PDF Abstract...
Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

by Michael | Sep 1, 2021 | New Publication

Digging into Dimerization: Way to go Morgan, Jillian, and the team! Our paper published in PNAS demonstrates robust dimerization of Ras induced by the Ras-binding domain (RBD) of Raf Kinase. Click here for the PDF Significance Ras GTPases, KRas, HRas, and NRas control...

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  • Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation